Role of Purines in Renal and Transplant Injury

Grant number: 1030463 | Funding period: 2012 - 2014

Completed

Abstract

Acute injury can lead to chronic immune activation in both chronic kidney disease and in transplantation. We will study the role of a class of molecules, the purines, that are released by injury and lead to immune activation. We will focus on the molecular variations and pharmacological blockade of their receptors as potential treatments for kidney disease and transplant graft failure.

Related publications (2)

Interleukin-33 Exacerbates IgA Glomerulonephritis in Transgenic Mice Overexpressing B Cell Activating Factor

YM Wang, K Shaw, GY Zhang, EYM Chung, M Hu, Q Cao, Y Wang, G Zheng, H Wu, SJ Chadban, HJ McCarthy, DCH Harris, F Mackay, ST Grey, SI Alexander

2022-05-01

Background The cytokine IL-33 is an activator of innate lymphoid cells 2 (ILC2s) in innate immunity and allergic inflammation. B c..

Regulatory T cells participate in CD39-mediated protection from renal injury

YM Wang, JL Mcrae, SC Robson, PJ Cowan, GY Zhang, M Hu, T Polhill, Y Wang, G Zheng, Y Wang, VWS Lee, RJ Unwin, DCH Harris, KM Dwyer, SI Alexander

2012-09-01

CD39 is an ecto-enzyme that degrades extracellular nucleotides, such as ATP, and is highly expressed on by the vasculature and cir..

University of Melbourne Researchers

Karen Dwyer